Bacterial Genomics and Pathogen Evolution

Overview

Journal Cell

Publisher Cell Press

Specialty Cell Biology

Date 2006 Feb 25

PMID 16497582

Citations 51

Authors

David M Raskin

Rekha Seshadri

Stefan U Pukatzki

John J Mekalanos

Affiliations

Soon will be listed here.

Abstract

The availability of hundreds of bacterial genome sequences has altered the study of bacterial pathogenesis, affecting both design of experiments and analysis of results. Comparative genomics and genomic tools have been used to identify virulence factors and genes involved in environmental persistence of pathogens. However, a major stumbling block in the genomics revolution has been the large number of genes with unknown function that have been identified in every organism sequenced to date.

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