Increased Cortical Atrophy in Patients with Alzheimer's Disease and Type 2 Diabetes Mellitus

Overview

Journal J Neurol Neurosurg Psychiatry

Publisher BMJ Publishing Group

Specialties Neurology
Neurosurgery
Psychiatry

Date 2006 Feb 18

PMID 16484636

Citations 32

Authors

G J Biessels

F-E de Leeuw

J Lindeboom

F Barkhof

P Scheltens

Affiliations

Soon will be listed here.

Abstract

Background: The risk of Alzheimer's disease (AD) is increased in type 2 diabetes (DM2). This increased risk has been attributed to vascular comorbidity, but other mechanisms, such as accelerated ageing of the brain, have also been implicated.

Objective: To determine whether AD in patients with DM2 is associated with an increased occurrence of vascular lesions in the brain, by increased cerebral atrophy, or a combination of both.

Methods: In total, 29 patients with AD and DM2 and 58 patients with AD and without DM2 were included in the study. Clinical characteristics were recorded, and a neuropsychological examination and magnetic resonance imaging (MRI) scan were performed. MRI scans were rated for cortical and subcortical atrophy, medial temporal lobe atrophy, white matter lesions, and infarcts.

Results: The neuropsychological profiles of the two groups were identical. Patients with AD and DM2 had increased cortical atrophy on MRI (p<0.05) compared with the non-DM2 group. In addition, infarcts were more common (odds ratio 2.4; 95% CI 0.8 to 7.8), but this effect did not account for the increased atrophy. The other MR measures did not differ between the groups.

Conclusion: The results suggest that non-vascular mechanisms, leading to increased cortical atrophy, are also involved in the increased risk of AD in DM2.

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References

Peila R, Rodriguez B, Launer L . Type 2 diabetes, APOE gene, and the risk for dementia and related pathologies: The Honolulu-Asia Aging Study. Diabetes. 2002; 51(4):1256-62. DOI: 10.2337/diabetes.51.4.1256. View

Biessels G, Koffeman A, Scheltens P . Diabetes and cognitive impairment. Clinical diagnosis and brain imaging in patients attending a memory clinic. J Neurol. 2005; 253(4):477-82. DOI: 10.1007/s00415-005-0036-4. View

Lindeboom J, Schmand B, Tulner L, Walstra G, Jonker C . Visual association test to detect early dementia of the Alzheimer type. J Neurol Neurosurg Psychiatry. 2002; 73(2):126-33. PMC: 1737993. DOI: 10.1136/jnnp.73.2.126. View

Vermeer S, den Heijer T, Koudstaal P, Oudkerk M, Hofman A, Breteler M . Incidence and risk factors of silent brain infarcts in the population-based Rotterdam Scan Study. Stroke. 2003; 34(2):392-6. DOI: 10.1161/01.str.0000052631.98405.15. View

Vermeer S, Prins N, den Heijer T, Hofman A, Koudstaal P, Breteler M . Silent brain infarcts and the risk of dementia and cognitive decline. N Engl J Med. 2003; 348(13):1215-22. DOI: 10.1056/NEJMoa022066. View

Gasparini L, Xu H . Potential roles of insulin and IGF-1 in Alzheimer's disease. Trends Neurosci. 2003; 26(8):404-6. DOI: 10.1016/S0166-2236(03)00163-2. View

Schmidt R, Launer L, Nilsson L, Pajak A, Sans S, Berger K . Magnetic resonance imaging of the brain in diabetes: the Cardiovascular Determinants of Dementia (CASCADE) Study. Diabetes. 2004; 53(3):687-92. DOI: 10.2337/diabetes.53.3.687. View

Ott A, Stolk R, Van Harskamp F, Pols H, Hofman A, Breteler M . Diabetes mellitus and the risk of dementia: The Rotterdam Study. Neurology. 1999; 53(9):1937-42. DOI: 10.1212/wnl.53.9.1937. View

Frolich L, Riederer P, Hoyer S . A disturbance in the neuronal insulin receptor signal transduction in sporadic Alzheimer's disease. Ann N Y Acad Sci. 2000; 893:290-3. DOI: 10.1111/j.1749-6632.1999.tb07839.x. View

10.

Schneider J, Wilson R, Bienias J, Evans D, Bennett D . Cerebral infarctions and the likelihood of dementia from Alzheimer disease pathology. Neurology. 2004; 62(7):1148-55. DOI: 10.1212/01.wnl.0000118211.78503.f5. View

11.

McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan E . Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology. 1984; 34(7):939-44. DOI: 10.1212/wnl.34.7.939. View

12.

Scheltens P, Barkhof F, Leys D, Pruvo J, Nauta J, Vermersch P . A semiquantative rating scale for the assessment of signal hyperintensities on magnetic resonance imaging. J Neurol Sci. 1993; 114(1):7-12. DOI: 10.1016/0022-510x(93)90041-v. View

13.

Roman G, Tatemichi T, Erkinjuntti T, Cummings J, Masdeu J, Garcia J . Vascular dementia: diagnostic criteria for research studies. Report of the NINDS-AIREN International Workshop. Neurology. 1993; 43(2):250-60. DOI: 10.1212/wnl.43.2.250. View

14.

Scheltens P, Launer L, Barkhof F, Weinstein H, van Gool W . Visual assessment of medial temporal lobe atrophy on magnetic resonance imaging: interobserver reliability. J Neurol. 1995; 242(9):557-60. DOI: 10.1007/BF00868807. View

15.

Mankovsky B, Metzger B, Molitch M, Biller J . Cerebrovascular disorders in patients with diabetes mellitus. J Diabetes Complications. 1996; 10(4):228-42. DOI: 10.1016/s1056-8727(96)90006-9. View

16.

Scheltens P, Pasquier F, Weerts J, Barkhof F, Leys D . Qualitative assessment of cerebral atrophy on MRI: inter- and intra-observer reproducibility in dementia and normal aging. Eur Neurol. 1997; 37(2):95-9. DOI: 10.1159/000117417. View

17.

Petrovitch H, Ross G, Steinhorn S, Abbott R, Markesbery W, Davis D . AD lesions and infarcts in demented and non-demented Japanese-American men. Ann Neurol. 2004; 57(1):98-103. DOI: 10.1002/ana.20318. View

18.

Biessels G, van der Heide L, Kamal A, Bleys R, Gispen W . Ageing and diabetes: implications for brain function. Eur J Pharmacol. 2002; 441(1-2):1-14. DOI: 10.1016/s0014-2999(02)01486-3. View