Potential Roles of Insulin and IGF-1 in Alzheimer's Disease

Overview

Journal Trends Neurosci

Specialty Neurology

Date 2003 Aug 6

PMID 12900169

Citations 91

Authors

Laura Gasparini

Huaxi Xu

Affiliations

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Abstract

Aging is characterized by a significant decline of metabolic and hormonal functions, which often facilitates the onset of severe age-associated pathologies. One outstanding example of this is the reported association of deranged signaling by insulin and insulin-like-growth-factor 1 (IGF-1) with Alzheimer's disease (AD). Recent compelling biological data reveal effects of insulin and IGF-1 on molecular and cellular mechanisms underlying the pathology of AD. This review discusses available biological data that highlight the therapeutic potential of the insulin-IGF-1 signaling pathway in AD.

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