» Articles » PMID: 16473963

Left Ventricular Hypertrophy in Mice with a Cardiac-specific Overexpression of Interleukin-1

Overview
Date 2006 Feb 14
PMID 16473963
Citations 22
Authors
Affiliations
Soon will be listed here.
Abstract

Recent studies have identified the importance of proinflammatory cytokines in the development of left ventricular (LV) hypertrophy. However, the precise role of interleukin-1 (IL-1), one of the major proinflammatory cytokines, in the myocardium is not fully understood. In this study, we investigated the pathophysiological consequences of cardiac expression of IL-1 in vivo. We generated mice with a cardiac-specific overexpression of human IL-1alpha. We then analyzed their heart morphology and functions. Histological and echocardiographic analyses revealed concentric LV hypertrophy with preserved LV systolic function in the mice. Our results suggest that myocardial expression of IL-1 is sufficient to cause LV hypertrophy.

Citing Articles

Sex Differences in Circulating Inflammatory, Immune, and Tissue Growth Markers Associated with Fabry Disease-Related Cardiomyopathy.

Ivanova M, Dao J, Friedman A, Kasaci N, Goker-Alpan O Cells. 2025; 14(5).

PMID: 40072051 PMC: 11899294. DOI: 10.3390/cells14050322.


Clinical-transcriptional prioritization of the circulating proteome in human heart failure.

Perry A, Amancherla K, Huang X, Lance M, Farber-Eger E, Gajjar P Cell Rep Med. 2024; 5(9):101704.

PMID: 39226894 PMC: 11524958. DOI: 10.1016/j.xcrm.2024.101704.


Cardiac Hypertrophy: From Pathophysiological Mechanisms to Heart Failure Development.

Caturano A, Vetrano E, Galiero R, Salvatore T, Docimo G, Epifani R Rev Cardiovasc Med. 2024; 23(5):165.

PMID: 39077592 PMC: 11273913. DOI: 10.31083/j.rcm2305165.


The Role of Pro-Inflammatory Cytokines in the Pathogenesis of Cardiovascular Disease.

Zhang H, Dhalla N Int J Mol Sci. 2024; 25(2).

PMID: 38256155 PMC: 10817020. DOI: 10.3390/ijms25021082.


Dynamic interplay between RPL3- and RPL3L-containing ribosomes modulates mitochondrial activity in the mammalian heart.

Milenkovic I, Santos Vieira H, Lucas M, Ruiz-Orera J, Patone G, Kesteven S Nucleic Acids Res. 2023; 51(11):5301-5324.

PMID: 36882085 PMC: 10287911. DOI: 10.1093/nar/gkad121.