Development of Specific Immunoglobulin Ga (IgGa) and IgGb Antibodies Correlates with Control of Parasitemia in Babesia Equi Infection

Overview

Journal Clin Vaccine Immunol

Publisher American Society for Microbiology

Specialties Allergy & Immunology
Pathology

Date 2006 Feb 10

PMID 16467341

Citations 7

Authors

Cristina W Cunha

Travis C McGuire

Lowell S Kappmeyer

Stephen A Hines

A Marianela Lopez

Odir A Dellagostin

Donald P Knowles

Affiliations

Soon will be listed here.

Abstract

In this study, the kinetics of specific immunoglobulin G (IgG) isotypes were characterized in Babesia equi (Theileria equi)-infected horses. IgGa and IgGb developed during acute infection, whereas IgG(T) was detected only after resolution of acute parasitemia. The same IgG isotype profile induced during acute infection was obtained by equi merozoite antigen 1/saponin immunization.

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References

Kappmeyer L, Perryman L, Knowles Jr D . A Babesia equi gene encodes a surface protein with homology to Theileria species. Mol Biochem Parasitol. 1993; 62(1):121-4. DOI: 10.1016/0166-6851(93)90185-z. View

Knowles Jr D, Kappmeyer L, Stiller D, Hennager S, Perryman L . Antibody to a recombinant merozoite protein epitope identifies horses infected with Babesia equi. J Clin Microbiol. 1992; 30(12):3122-6. PMC: 270599. DOI: 10.1128/jcm.30.12.3122-3126.1992. View

Boehm U, Klamp T, Groot M, Howard J . Cellular responses to interferon-gamma. Annu Rev Immunol. 1997; 15:749-95. DOI: 10.1146/annurev.immunol.15.1.749. View

Lunn D, Holmes M, Antczak D, Agerwal N, Baker J, Byrne K . Report of the Second Equine Leucocyte Antigen Workshop, Squaw valley, California, July 1995. Vet Immunol Immunopathol. 1998; 62(2):101-43. DOI: 10.1016/s0165-2427(97)00160-8. View

Sheoran A, Lunn D, Holmes M . Monoclonal antibodies to subclass-specific antigenic determinants on equine immunoglobulin gamma chains and their characterization. Vet Immunol Immunopathol. 1998; 62(2):153-65. DOI: 10.1016/s0165-2427(97)00162-1. View

Mehlhorn H, Schein E . Redescription of Babesia equi Laveran, 1901 as Theileria equi Mehlhorn, Schein 1998. Parasitol Res. 1998; 84(6):467-75. DOI: 10.1007/s004360050431. View

Brown W, Mcelwain T, Palmer G, Chantler S, Estes D . Bovine CD4(+) T-lymphocyte clones specific for rhoptry-associated protein 1 of Babesia bigemina stimulate enhanced immunoglobulin G1 (IgG1) and IgG2 synthesis. Infect Immun. 1998; 67(1):155-64. PMC: 96291. DOI: 10.1128/IAI.67.1.155-164.1999. View

Lunn D, Soboll G, Schram B, Quass J, McGREGOR M, Drape R . Antibody responses to DNA vaccination of horses using the influenza virus hemagglutinin gene. Vaccine. 1999; 17(18):2245-58. DOI: 10.1016/s0264-410x(98)00496-4. View

Ueti M, Palmer G, Kappmeyer L, Statdfield M, Scoles G, Knowles D . Ability of the vector tick Boophilus microplus to acquire and transmit Babesia equi following feeding on chronically infected horses with low-level parasitemia. J Clin Microbiol. 2005; 43(8):3755-9. PMC: 1233951. DOI: 10.1128/JCM.43.8.3755-3759.2005. View

10.

Brown W, Palmer G . Designing blood-stage vaccines against Babesia bovis and B. bigemina. Parasitol Today. 1999; 15(7):275-81. DOI: 10.1016/s0169-4758(99)01471-4. View

11.

Chen D, Copeman D, Burnell J, Hutchinson G . Helper T cell and antibody responses to infection of CBA mice with Babesia microti. Parasite Immunol. 2000; 22(2):81-8. DOI: 10.1046/j.1365-3024.2000.00279.x. View

12.

Aucan C, Traore Y, Tall F, Nacro B, Fumoux F, Rihet P . High immunoglobulin G2 (IgG2) and low IgG4 levels are associated with human resistance to Plasmodium falciparum malaria. Infect Immun. 2000; 68(3):1252-8. PMC: 97275. DOI: 10.1128/IAI.68.3.1252-1258.2000. View

13.

Sheoran A, Timoney J, Holmes M, Karzenski S, Crisman M . Immunoglobulin isotypes in sera and nasal mucosal secretions and their neonatal transfer and distribution in horses. Am J Vet Res. 2000; 61(9):1099-105. DOI: 10.2460/ajvr.2000.61.1099. View

14.

Chen D, Copeman D, Hutchinson G, Burnell J . Inhibition of growth of cultured Babesia microti by serum and macrophages in the presence or absence of T cells. Parasitol Int. 2001; 48(3):223-31. DOI: 10.1016/s1383-5769(99)00022-7. View

15.

Cavinato R, Bastos K, Sardinha L, Elias R, Alvarez J, DImperio Lima M . Susceptibility of the different developmental stages of the asexual (schizogonic) erythrocyte cycle of Plasmodium chabaudi chabaudi to hyperimmune serum, immunoglobulin (Ig)G1, IgG2a and F(ab')2 fragments. Parasite Immunol. 2001; 23(11):587-97. DOI: 10.1046/j.1365-3024.2001.00419.x. View

16.

Brown W . Molecular approaches to elucidating innate and acquired immune responses to Babesia bovis, a protozoan parasite that causes persistent infection. Vet Parasitol. 2001; 101(3-4):233-48. DOI: 10.1016/s0304-4017(01)00569-6. View

17.

Mizukoshi F, Maeda K, Hamano M, Iwata H, Matsumura T, Kondo T . IgG antibody subclass response against equine herpesvirus type 4 in horses. Vet Immunol Immunopathol. 2002; 88(1-2):97-101. DOI: 10.1016/s0165-2427(02)00130-7. View

18.

Lopez A, Hines M, Palmer G, Alperin D, Hines S . Identification of pulmonary T-lymphocyte and serum antibody isotype responses associated with protection against Rhodococcus equi. Clin Diagn Lab Immunol. 2002; 9(6):1270-6. PMC: 130094. DOI: 10.1128/cdli.9.6.1270-1276.2002. View

19.

Wagner B, Miller D, Lear T, Antczak D . The complete map of the Ig heavy chain constant gene region reveals evidence for seven IgG isotypes and for IgD in the horse. J Immunol. 2004; 173(5):3230-42. DOI: 10.4049/jimmunol.173.5.3230. View

20.

Frerichs W, HOLBROOK A, Johnson A . Equine piroplasmosis: production of antigens for the complement-fixation test. Am J Vet Res. 1969; 30(8):1337-41. View