Role of Positive Selection in the Retention of Duplicate Genes in Mammalian Genomes

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2006 Feb 8

PMID 16461903

Citations 42

Authors

Shin-Han Shiu

Jake K Byrnes

Runsun Pan

Peng Zhang

Wen-Hsiung Li

Affiliations

Soon will be listed here.

Abstract

The question of how duplicate genes are retained in a population remains controversial. The duplication-degeneration-complementation model, which involves no positive selection, stipulates a higher retention rate of duplicate genes in a small population than in a large one. This model has been accepted by many evolutionists. However, we found considerably more retentions and fewer losses of duplicate genes in the mouse genome than in the human genome, although the population size of rodents is in general larger than that of primates. Indeed, in nearly every interval of synonymous divergence between duplicate genes, the number of gene retentions in mouse is larger than that in human. Our findings suggest a more important role of positive selection in duplicate retention than duplication-degeneration-complementation. In addition, certain functional categories show a higher tendency of lineage-specific expansion than expected, suggesting lineage-specific selection or functional bias in retained duplicates.

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