Deletions in Processed Pseudogenes Accumulate Faster in Rodents Than in Humans

Overview

Journal J Mol Evol

Specialty Biochemistry

Date 1989 Apr 1

PMID 2499684

Citations 45

Authors

D Graur

Y Shuali

W H Li

Affiliations

Soon will be listed here.

Abstract

The relative rates of point nucleotide substitution and accumulation of gap events (deletions and insertions) were calculated for 22 human and 30 rodent processed pseudogenes. Deletion events not only outnumbered insertions (the ratio being 7:1 and 3:1 for human and rodent pseudogenes, respectively), but also the total length of deletions was greater than that of insertions. Compared with their functional homologs, human processed pseudogenes were found to be shorter by about 1.2%, and rodent pseudogenes by about 2.3%. DNA loss from processed pseudogenes through deletion is estimated to be at least seven times faster in rodents than in humans. In comparison with the rate of point substitutions, the abridgment of pseudogenes during evolutionary times is a slow process that probably does not retard the rate of growth of the genome due to the proliferation of processed pseudogenes.

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