Enhanced SMYD3 Expression is Essential for the Growth of Breast Cancer Cells

Overview

Journal Cancer Sci

Specialty Oncology

Date 2006 Jan 31

PMID 16441421

Citations 132

Authors

Ryuji Hamamoto

Fabio Pittella Silva

Masataka Tsuge

Toshihiko Nishidate

Toyomasa Katagiri

Yusuke Nakamura

Yoichi Furukawa

Affiliations

Soon will be listed here.

Abstract

We previously reported that upregulation of SMYD3, a histone H3 lysine-4-specific methyltransferase, plays a key role in the proliferation of colorectal carcinoma (CRC) and hepatocellular carcinoma (HCC). In the present study, we reveal that SMYD3 expression is also elevated in the great majority of breast cancer tissues. Similarly to CRC and HCC, silencing of SMYD3 by small interfering RNA to this gene resulted in the inhibited growth of breast cancer cells, suggesting that increased SMYD3 expression is also essential for the proliferation of breast cancer cells. Moreover, we show here that SMYD3 could promote breast carcinogenesis by directly regulating expression of the proto-oncogene WNT10B. These data imply that augmented SMYD3 expression plays a crucial role in breast carcinogenesis, and that inhibition of SMYD3 should be a novel therapeutic strategy for treatment of breast cancer.

Citing Articles

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SMYD3 promotes endometrial cancer through epigenetic regulation of LIG4/XRCC4/XLF complex in non-homologous end joining repair.

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