» Articles » PMID: 16437679

Tumor Necrosis Factor-alpha-induced Protein 1 and Immunity to Hepatitis B Virus

Overview
Specialty Gastroenterology
Date 2006 Jan 27
PMID 16437679
Citations 6
Authors
Affiliations
Soon will be listed here.
Abstract

Aim: To compare the gene expression profile in a pair of HBV-infected twins.

Methods: The gene expression profile was compared in a pair of HBV-infected twins.

Results: The twins displayed different disease outcomes. One acquired natural immunity against HBV, whereas the other became a chronic HBV carrier. Eighty-eight and forty-six genes were found to be up- or down-regulated in their PBMCs, respectively. Tumor necrosis factor-alpha-induced protein 1 (TNF-alphaIP1) that expressed at a higher level in the HBV-immune twins was identified and four pairs of siblings with HBV immunity by RT-PCR. However, upon HBV core antigen stimulation, TNF-alphaIP1 was downregulated in PBMCs from subjects with immunity, whereas it was slightly upregulated in HBV carriers. Bioinformatics analysis revealed a K+ channel tetramerization domain in TNF-alphaIP1 that shares a significant homology with some human, mouse, and C elegan proteins.

Conclusion: TNF-alphaIP1 may play a role in the innate immunity against HBV.

Citing Articles

CRISPR/Cas9-Mediated Knockout of in Zebrafish Plays a Role in Early Development.

Huang S, Zhang H, Chen W, Su N, Yuan C, Zhang J Genes (Basel). 2023; 14(5).

PMID: 37239365 PMC: 10217809. DOI: 10.3390/genes14051005.


Aberrant expression of miR-16, B12 and CD272 in peripheral blood mononuclear cells from patients with active tuberculosis.

Lin D, Liu Q, Wang W, Li Y, Li Y, Lin B Am J Transl Res. 2020; 12(10):6076-6091.

PMID: 33194015 PMC: 7653578.


Tumor necrosis factor α-induced protein 1 as a novel tumor suppressor through selective downregulation of CSNK2B blocks nuclear factor-κB activation in hepatocellular carcinoma.

Xiao Y, Huang S, Qiu F, Ding X, Sun Y, Wei C EBioMedicine. 2020; 51:102603.

PMID: 31901862 PMC: 6950786. DOI: 10.1016/j.ebiom.2019.102603.


TNFAIP1 interacts with KCTD10 to promote the degradation of KCTD10 proteins and inhibit the transcriptional activities of NF-κB and AP-1.

Hu X, Yan F, Wang F, Yang Z, Xiao L, Li L Mol Biol Rep. 2012; 39(11):9911-9.

PMID: 22810651 DOI: 10.1007/s11033-012-1858-7.


CK2 phosphorylates TNFAIP1 to affect its subcellular localization and interaction with PCNA.

Yang L, Liu N, Hu X, Zhang W, Wang T, Li H Mol Biol Rep. 2009; 37(6):2967-73.

PMID: 19851886 DOI: 10.1007/s11033-009-9863-1.


References
1.
Peiser L, Mukhopadhyay S, Gordon S . Scavenger receptors in innate immunity. Curr Opin Immunol. 2002; 14(1):123-8. DOI: 10.1016/s0952-7915(01)00307-7. View

2.
Lok A, Lai C, Wu P, Wong V, Yeoh E, Lin H . Hepatitis B virus infection in Chinese families in Hong Kong. Am J Epidemiol. 1987; 126(3):492-9. DOI: 10.1093/oxfordjournals.aje.a114681. View

3.
Romero R, Lavine J . Cytokine inhibition of the hepatitis B virus core promoter. Hepatology. 1996; 23(1):17-23. DOI: 10.1002/hep.510230103. View

4.
Biermer M, Puro R, Schneider R . Tumor necrosis factor alpha inhibition of hepatitis B virus replication involves disruption of capsid Integrity through activation of NF-kappaB. J Virol. 2003; 77(7):4033-42. PMC: 150632. DOI: 10.1128/jvi.77.7.4033-4042.2003. View

5.
Stevens C, Beasley R, Tsui J, Lee W . Vertical transmission of hepatitis B antigen in Taiwan. N Engl J Med. 1975; 292(15):771-4. DOI: 10.1056/NEJM197504102921503. View