Estrogen Receptor Beta, a Possible Tumor Suppressor Involved in Ovarian Carcinogenesis

Overview

Journal Cancer Lett

Specialty Oncology

Date 2006 Jan 10

PMID 16399219

Citations 55

Authors

Gwendal Lazennec

Affiliations

Soon will be listed here.

Abstract

Ovarian cancer is one of the leading causes of death from gynecological tumors in women. Several lines of evidence suggest that estrogens may play an important role in ovarian carcinogenesis, through their receptors, ERalpha and ERbeta. Interestingly, malignant ovarian tumors originating from epithelial surface constitute about 90% of ovarian cancers and expressed low levels of ERbeta, compared to normal tissues. In addition, restoration of ERbeta in ovarian cancer cells, leads to strong inhibition of their proliferation and invasion, while apoptosis is enhanced. In this manuscript, recent data suggesting a possible tumor-suppressor role for ERbeta in ovarian carcinogenesis are discussed.

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References

Enmark E, Pelto-Huikko M, Grandien K, Lagercrantz S, Lagercrantz J, Fried G . Human estrogen receptor beta-gene structure, chromosomal localization, and expression pattern. J Clin Endocrinol Metab. 1997; 82(12):4258-65. DOI: 10.1210/jcem.82.12.4470. View

Brandenberger A, Tee M, Jaffe R . Estrogen receptor alpha (ER-alpha) and beta (ER-beta) mRNAs in normal ovary, ovarian serous cystadenocarcinoma and ovarian cancer cell lines: down-regulation of ER-beta in neoplastic tissues. J Clin Endocrinol Metab. 1998; 83(3):1025-8. DOI: 10.1210/jcem.83.3.4788. View

Hillier S, Anderson R, Williams A, Tetsuka M . Expression of oestrogen receptor alpha and beta in cultured human ovarian surface epithelial cells. Mol Hum Reprod. 1998; 4(8):811-5. DOI: 10.1093/molehr/4.8.811. View

Risch H . Hormonal etiology of epithelial ovarian cancer, with a hypothesis concerning the role of androgens and progesterone. J Natl Cancer Inst. 1998; 90(23):1774-86. DOI: 10.1093/jnci/90.23.1774. View

Pujol P, Rey J, Nirde P, Roger P, Gastaldi M, Laffargue F . Differential expression of estrogen receptor-alpha and -beta messenger RNAs as a potential marker of ovarian carcinogenesis. Cancer Res. 1998; 58(23):5367-73. View

Dubeau L . The cell of origin of ovarian epithelial tumors and the ovarian surface epithelium dogma: does the emperor have no clothes?. Gynecol Oncol. 1999; 72(3):437-42. DOI: 10.1006/gyno.1998.5275. View

Riman T, Persson I, Nilsson S . Hormonal aspects of epithelial ovarian cancer: review of epidemiological evidence. Clin Endocrinol (Oxf). 1999; 49(6):695-707. DOI: 10.1046/j.1365-2265.1998.00577.x. View

. A unified nomenclature system for the nuclear receptor superfamily. Cell. 1999; 97(2):161-3. DOI: 10.1016/s0092-8674(00)80726-6. View

Lau K, Mok S, Ho S . Expression of human estrogen receptor-alpha and -beta, progesterone receptor, and androgen receptor mRNA in normal and malignant ovarian epithelial cells. Proc Natl Acad Sci U S A. 1999; 96(10):5722-7. PMC: 21927. DOI: 10.1073/pnas.96.10.5722. View

10.

Schomberg D, Couse J, Mukherjee A, Lubahn D, Sar M, Mayo K . Targeted disruption of the estrogen receptor-alpha gene in female mice: characterization of ovarian responses and phenotype in the adult. Endocrinology. 1999; 140(6):2733-44. DOI: 10.1210/endo.140.6.6823. View

11.

Couse J, Korach K . Estrogen receptor null mice: what have we learned and where will they lead us?. Endocr Rev. 1999; 20(3):358-417. DOI: 10.1210/edrv.20.3.0370. View

12.

Lazennec G, Katzenellenbogen B . Expression of human estrogen receptor using an efficient adenoviral gene delivery system is able to restore hormone-dependent features to estrogen receptor-negative breast carcinoma cells. Mol Cell Endocrinol. 1999; 149(1-2):93-105. DOI: 10.1016/s0303-7207(98)00254-8. View

13.

Skliris G, Munot K, Bell S, Carder P, Lane S, Horgan K . Reduced expression of oestrogen receptor beta in invasive breast cancer and its re-expression using DNA methyl transferase inhibitors in a cell line model. J Pathol. 2003; 201(2):213-20. DOI: 10.1002/path.1436. View

14.

Speirs V, Malone C, Walton D, Kerin M, Atkin S . Increased expression of estrogen receptor beta mRNA in tamoxifen-resistant breast cancer patients. Cancer Res. 1999; 59(21):5421-4. View

15.

Kelley S, Thackray V . Phylogenetic analyses reveal ancient duplication of estrogen receptor isoforms. J Mol Evol. 1999; 49(5):609-14. DOI: 10.1007/pl00006582. View

16.

Jarvinen T, Pelto-Huikko M, Holli K, Isola J . Estrogen receptor beta is coexpressed with ERalpha and PR and associated with nodal status, grade, and proliferation rate in breast cancer. Am J Pathol. 2000; 156(1):29-35. PMC: 1868617. DOI: 10.1016/s0002-9440(10)64702-5. View

17.

Foley E, Jazaeri A, Shupnik M, Jazaeri O, Rice L . Selective loss of estrogen receptor beta in malignant human colon. Cancer Res. 2000; 60(2):245-8. View

18.

Chu S, Mamers P, Burger H, Fuller P . Estrogen receptor isoform gene expression in ovarian stromal and epithelial tumors. J Clin Endocrinol Metab. 2000; 85(3):1200-5. DOI: 10.1210/jcem.85.3.6449. View

19.

Mcgee E, Hsueh A . Initial and cyclic recruitment of ovarian follicles. Endocr Rev. 2000; 21(2):200-14. DOI: 10.1210/edrv.21.2.0394. View

20.

Coughlin S, Giustozzi A, Smith S, Lee N . A meta-analysis of estrogen replacement therapy and risk of epithelial ovarian cancer. J Clin Epidemiol. 2000; 53(4):367-75. DOI: 10.1016/s0895-4356(99)00179-1. View