Inflamed Fat: What Starts the Fire?

Overview

Journal J Clin Invest

Specialty General Medicine

Date 2006 Jan 6

PMID 16395402

Citations 163

Authors

Jaap G Neels

Jerrold M Olefsky

Affiliations

Soon will be listed here.

Abstract

Obesity is associated with increased macrophage infiltration of adipose tissue, and these macrophages may be an important component of the chronic inflammatory response playing a crucial role in the development of insulin resistance. This prompts the question as to how macrophages infiltrate obese adipose tissue. In this issue of the JCI, Weisberg et al. show the importance of C-C motif chemokine receptor 2 (CCR2) in macrophage recruitment to adipose tissue and the development of obesity and its complications.

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