Tumor Suppression and Normal Aging in Mice with Constitutively High P53 Activity

Overview

Journal Genes Dev

Specialty Molecular Biology

Date 2006 Jan 5

PMID 16391230

Citations 114

Authors

Susan M Mendrysa

Kathleen A OLeary

Matthew K McElwee

Jennifer Michalowski

Robert N Eisenman

Douglas A Powell

Mary Ellen Perry

Affiliations

Soon will be listed here.

Abstract

The p53 inhibitor murine double-minute gene 2 (Mdm2) is a target for potential cancer therapies, however increased p53 function can be lethal. To directly address whether reduced Mdm2 function can inhibit tumorigenesis without causing detrimental side effects, we exploited a hypomorphic murine allele of mdm2 to compare the effects of decreased levels of Mdm2 and hence increased p53 activity on tumorigenesis and life span in mice. Here we report that mice with decreased levels of Mdm2 are resistant to tumor formation yet do not age prematurely, supporting the notion that Mdm2 is a promising target for cancer therapeutics.

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