Norfloxacin Blood-brain Barrier Transport in Rats is Not Affected by Probenecid Coadministration

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 2005 Dec 27

PMID 16377715

Citations 3

Authors

Sandrine Marchand

Anna Forsell

Marylore Chenel

Emmanuelle Comets

Isabelle Lamarche

William Couet

Affiliations

Soon will be listed here.

Abstract

The effect of probenecid (PRO) on norfloxacin (NOR) blood-brain barrier transport was investigated with rats by microdialysis. Maximum brain drug concentrations were rapidly attained, and the brain penetration factor was close to 5% in the absence and presence of PRO. In conclusion, PRO has no effect on NOR blood-brain barrier transport.

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