Inhibition of Macrophage Apoptosis by Neisseria Meningitidis Requires Nitric Oxide Detoxification Mechanisms

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 2005 Dec 22

PMID 16369030

Citations 23

Authors

Anne J Tunbridge

Tania M Stevanin

Margaret Lee

Helen M Marriott

James W B Moir

Robert C Read

David H Dockrell

Affiliations

Soon will be listed here.

Abstract

Host-driven macrophage apoptosis contributes to innate immunity during bacterial infection. Neisseria meningitidis inhibits apoptosis in a variety of cells, but its impact on macrophage apoptosis is unknown. We demonstrate that N. meningitidis prevents macrophage apoptosis via genes encoding nitric oxide detoxification and a porin, PorB.

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References

Marriott H, Bingle C, Read R, Braley K, Kroemer G, Hellewell P . Dynamic changes in Mcl-1 expression regulate macrophage viability or commitment to apoptosis during bacterial clearance. J Clin Invest. 2005; 115(2):359-68. PMC: 544034. DOI: 10.1172/JCI21766. View

Lammas D, Stober C, Harvey C, Kendrick N, Panchalingam S, Kumararatne D . ATP-induced killing of mycobacteria by human macrophages is mediated by purinergic P2Z(P2X7) receptors. Immunity. 1997; 7(3):433-44. DOI: 10.1016/s1074-7613(00)80364-7. View

Stevanin T, Moir J, Read R . Nitric oxide detoxification systems enhance survival of Neisseria meningitidis in human macrophages and in nasopharyngeal mucosa. Infect Immun. 2005; 73(6):3322-9. PMC: 1111883. DOI: 10.1128/IAI.73.6.3322-3329.2005. View

Massari P, Ho Y, Wetzler L . Neisseria meningitidis porin PorB interacts with mitochondria and protects cells from apoptosis. Proc Natl Acad Sci U S A. 2000; 97(16):9070-5. PMC: 16823. DOI: 10.1073/pnas.97.16.9070. View

Liu H, Perlman H, Pagliari L, Pope R . Constitutively activated Akt-1 is vital for the survival of human monocyte-differentiated macrophages. Role of Mcl-1, independent of nuclear factor (NF)-kappaB, Bad, or caspase activation. J Exp Med. 2001; 194(2):113-26. PMC: 2193455. DOI: 10.1084/jem.194.2.113. View

Dockrell D, Lee M, Lynch D, Read R . Immune-mediated phagocytosis and killing of Streptococcus pneumoniae are associated with direct and bystander macrophage apoptosis. J Infect Dis. 2001; 184(6):713-22. DOI: 10.1086/323084. View

Anjum M, Stevanin T, Read R, Moir J . Nitric oxide metabolism in Neisseria meningitidis. J Bacteriol. 2002; 184(11):2987-93. PMC: 135047. DOI: 10.1128/JB.184.11.2987-2993.2002. View

Emonts M, Hazelzet J, de Groot R, Hermans P . Host genetic determinants of Neisseria meningitidis infections. Lancet Infect Dis. 2003; 3(9):565-77. DOI: 10.1016/s1473-3099(03)00740-0. View

Ali F, Lee M, Iannelli F, Pozzi G, Mitchell T, Read R . Streptococcus pneumoniae-associated human macrophage apoptosis after bacterial internalization via complement and Fcgamma receptors correlates with intracellular bacterial load. J Infect Dis. 2003; 188(8):1119-31. DOI: 10.1086/378675. View

10.

Callahan M, Halleck M, Krahling S, Henderson A, Williamson P, Schlegel R . Phosphatidylserine expression and phagocytosis of apoptotic thymocytes during differentiation of monocytic cells. J Leukoc Biol. 2003; 74(5):846-56. DOI: 10.1189/jlb.0902433. View

11.

DeLeo F . Modulation of phagocyte apoptosis by bacterial pathogens. Apoptosis. 2004; 9(4):399-413. DOI: 10.1023/B:APPT.0000031448.64969.fa. View

12.

Marriott H, Ali F, Read R, Mitchell T, Whyte M, Dockrell D . Nitric oxide levels regulate macrophage commitment to apoptosis or necrosis during pneumococcal infection. FASEB J. 2004; 18(10):1126-8. DOI: 10.1096/fj.03-1450fje. View

13.

Zhang Y, Hogg N . Formation and stability of S-nitrosothiols in RAW 264.7 cells. Am J Physiol Lung Cell Mol Physiol. 2003; 287(3):L467-74. DOI: 10.1152/ajplung.00350.2003. View

14.

Robinson K, Taraktsoglou M, Rowe K, Wooldridge K, AlaAldeen D . Secreted proteins from Neisseria meningitidis mediate differential human gene expression and immune activation. Cell Microbiol. 2004; 6(10):927-38. DOI: 10.1111/j.1462-5822.2004.00410.x. View

15.

PIPKORN U, Karlsson G, Enerback L . A brush method to harvest cells from the nasal mucosa for microscopic and biochemical analysis. J Immunol Methods. 1988; 112(1):37-42. DOI: 10.1016/0022-1759(88)90030-0. View

16.

Tommassen J, Vermeij P, Struyve M, Benz R, Poolman J . Isolation of Neisseria meningitidis mutants deficient in class 1 (porA) and class 3 (porB) outer membrane proteins. Infect Immun. 1990; 58(5):1355-9. PMC: 258632. DOI: 10.1128/iai.58.5.1355-1359.1990. View

17.

Read R, Fox A, Miller K, Gray T, Jones N, Borrows R . Experimental infection of human nasal mucosal explants with Neisseria meningitidis. J Med Microbiol. 1995; 42(5):353-61. DOI: 10.1099/00222615-42-5-353. View

18.

Read R, Zimmerli S, Broaddus C, Sanan D, Stephens D, Ernst J . The (alpha2-->8)-linked polysialic acid capsule of group B Neisseria meningitidis modifies multiple steps during interaction with human macrophages. Infect Immun. 1996; 64(8):3210-7. PMC: 174209. DOI: 10.1128/iai.64.8.3210-3217.1996. View

19.

Messmer U, Brune B . Nitric oxide-induced apoptosis: p53-dependent and p53-independent signalling pathways. Biochem J. 1996; 319 ( Pt 1):299-305. PMC: 1217768. DOI: 10.1042/bj3190299. View

20.

Zychlinsky A, Sansonetti P . Perspectives series: host/pathogen interactions. Apoptosis in bacterial pathogenesis. J Clin Invest. 1997; 100(3):493-5. PMC: 508214. DOI: 10.1172/JCI119557. View