Bmp Signaling: Turning a Half into a Whole

Overview

Journal Cell

Publisher Cell Press

Specialty Cell Biology

Date 2005 Dec 20

PMID 16360027

Citations 7

Authors

David Kimelman

Ujwal J Pyati

Affiliations

Soon will be listed here.

Abstract

In a famous experiment over a century ago, Hans Spemann demonstrated that amphibians have a remarkable ability to compensate for perturbations to the embryo. In this issue of Cell, Reversade and De Robertis (2005) uncover the basis of this phenomenon. They demonstrate that interactions between bone morphogenetic proteins (Bmps) and their inhibitors on both the dorsal and ventral sides of the early Xenopus embryo are involved in creating the body plan.

Citing Articles

BMP Signaling: Lighting up the Way for Embryonic Dorsoventral Patterning.

Yan Y, Wang Q Front Cell Dev Biol. 2022; 9:799772.

PMID: 35036406 PMC: 8753366. DOI: 10.3389/fcell.2021.799772.

Controlling the Messenger: Regulated Translation of Maternal mRNAs in Xenopus laevis Development.

Sheets M, Fox C, Dowdle M, Blaser S, Chung A, Park S Adv Exp Med Biol. 2016; 953:49-82.

PMID: 27975270 PMC: 5652302. DOI: 10.1007/978-3-319-46095-6_2.

A deuterostome origin of the Spemann organiser suggested by Nodal and ADMPs functions in Echinoderms.

Lapraz F, Haillot E, Lepage T Nat Commun. 2015; 6:8434.

PMID: 26423516 PMC: 4600745. DOI: 10.1038/ncomms9434.

BMP10 inhibited the growth and migration of gastric cancer cells.

Lei H, Wang J, Lu P, Si X, Han K, Ruan T Tumour Biol. 2015; 37(3):3025-31.

PMID: 26419594 DOI: 10.1007/s13277-015-4116-5.

Temporal regulation of mRNAs for select bone morphogenetic proteins (BMP), BMP receptors and their associated SMAD proteins during bovine early embryonic development: effects of exogenous BMP2 on embryo developmental progression.

Lee K, Folger J, Rajput S, Smith G Reprod Biol Endocrinol. 2014; 12:67.

PMID: 25027287 PMC: 4110370. DOI: 10.1186/1477-7827-12-67.