Tectonic, a Novel Regulator of the Hedgehog Pathway Required for Both Activation and Inhibition

Overview

Journal Genes Dev

Specialty Molecular Biology

Date 2005 Dec 17

PMID 16357211

Citations 69

Authors

Jeremy F Reiter

William C Skarnes

Affiliations

Soon will be listed here.

Abstract

We report the identification of a novel protein that participates in Hedgehog-mediated patterning of the neural tube. This protein, named Tectonic, is the founding member of a previously undescribed family of evolutionarily conserved secreted and transmembrane proteins. During neural tube development, mouse Tectonic is required for formation of the most ventral cell types and for full Hedgehog (Hh) pathway activation. Epistasis analyses reveal that Tectonic modulates Hh signal transduction downstream of Smoothened (Smo) and Rab23. Interestingly, characterization of Tectonic Shh and Tectonic Smo double mutants indicates that Tectonic plays an additional role in repressing Hh pathway activity.

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