BDNF Genetic Variants Are Associated with Onset Age of Familial Parkinson Disease: GenePD Study

Overview

Journal Neurology

Specialty Neurology

Date 2005 Dec 14

PMID 16344533

Citations 25

Authors

S Karamohamed

J C Latourelle

B A Racette

J S Perlmutter

G F Wooten

M Lew

C Klein

H Shill

L I Golbe

M H Mark

M Guttman

G Nicholson

J B Wilk

M Saint-Hilaire

A L DeStefano

R Prakash

S Tobin

J Williamson

O Suchowersky

N Labell

B N J Growdon

C Singer

R Watts

S Goldwurm

G Pezzoli

K B Baker

M L Giroux

P P Pramstaller

D J Burn

P Chinnery

S Sherman

P Vieregge

I Litvan

J F Gusella

R H Myers

A Parsian

Affiliations

Soon will be listed here.

Abstract

Brain-derived neurotrophic factor (BDNF) stimulates neuronal growth and protects nigral dopamine neurons in animal models of Parkinson disease (PD). Therefore, BDNF is a candidate gene for PD. The authors investigated five single-nucleotide polymorphisms in 597 cases of familial PD. Homozygosity for the rare allele of the functional BDNF G196A (Val66Met) variant was associated with a 5.3-year older onset age (p = 0.0001). These findings suggest that BDNF may influence PD onset age.

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