Polyoma Virus T Antigen. I. Synthesis of Modified Heat-labile T Angiten in Cells Transformed with the Ts-a Mutant

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 1975 Feb 1

PMID 163363

Citations 16

Authors

D Paulin

F Cuzin

Affiliations

Soon will be listed here.

Abstract

In mouse cells transformed with the ts-a mutant of polyoma virus (ts-a-3T3), only low amounts of the virus-specific T antigen were synthesized at high temperature (39 C). After a shift-down to the permissive temperature (31 C), these cells exhibited the same level of T-antigen production as wild-type polyoma transformants. The T antigen produced by ts-a-transformed cells was inactivated at 39 C in vitro at a faster rate than that produced by wild-type-transformed cells. These observations indicate that T antigen is, or includes, a virus-coded peptide.

Citing Articles

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Characterization of polyoma mutants with altered middle and large T-antigens.

Magnusson G, Nilsson M, Dilworth S, Smolar N J Virol. 1981; 39(3):673-83.

PMID: 6270343 PMC: 171301. DOI: 10.1128/JVI.39.3.673-683.1981.

Nucleotide sequence changes in polyoma virus A gene mutants.

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The tumor antigens and the early functions of polyoma virus.

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Initiation of polyoma virus DNA replication in vitro and its dependence on the viral gene A protein.

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