Phylogenetic Relationship of the Populations Within and Around Japan Using 105 Short Tandem Repeat Polymorphic Loci

Overview

Journal Hum Genet

Specialty Genetics

Date 2005 Nov 30

PMID 16315063

Citations 7

Authors

Shi-Lin Li

Toshimichi Yamamoto

Takashi Yoshimoto

Rieko Uchihi

Masaki Mizutani

Yukihide Kurimoto

Katsushi Tokunaga

Feng Jin

Yoshinao Katsumata

Naruya Saitou

Affiliations

Soon will be listed here.

Abstract

We have analyzed 105 autosomal polymorphic short tandem repeat (STR) loci for nine East and South-eastern Asian populations (two Japanese, five Han Chinese, Thai, and Burmese populations) and a Caucasian population using a multiplex PCR typing system. All the STR loci are genomewide tetranucleotide repeat markers of which the total number of observed alleles and the observed heterozygosity were 756 and 0.743, respectively, for Japanese populations. Phylogenetic analysis for these allele frequency data suggested that the Japanese populations are more closely related with southern Chinese populations than central and/or northern ones. STRUCTURE program analysis revealed the almost clearly divided and accountable population structure at K=2-6, that the two Japanese populations always formed one group separated from the other populations and never belong to different groups at K> or =3. Furthermore, our new allele frequency data for 91 loci were analyzed with those for 52 worldwide populations published by previous studies. Phylogenetic and multidimensional scaling (MDS) analyses indicated that Asian populations with large population size (six Han Chinese, three Japanese, two Southeast Asia) formed one distinct cluster and are closer to each other than other ethnic minorities in east and Southeast Asia. This pattern may be the caviar of comparing populations with greatly differing population sizes when STR loci were analyzed.

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