Adipose Tissue As Source and Target for Novel Therapies

Overview

Journal Trends Endocrinol Metab

Specialty Endocrinology

Date 2005 Nov 29

PMID 16309918

Citations 13

Authors

Johannes Klein

Nina Perwitz

Daniel Kraus

Mathias Fasshauer

Affiliations

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Abstract

The physiology of adipose tissue has a key role in the pathogenesis of the metabolic syndrome and related cardiovascular disorders. Three main functions of adipocytes have been proposed to explain this role: the secretion of adipocyte-derived hormones (so-called adipokines), energy dissipation/thermogenesis, and energy storage. There is mounting evidence that this repertoire of actions and reactions contributes to whole-body glucose and energy homeostasis, the control of blood pressure, immune-system function, haemostasis and atherosclerosis. In this article we highlight the most recent examples of adipocyte-based therapies and discuss future pharmacological options for exploiting this triad of adipocyte functions.

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