Novel Biomarkers and Endoscopic Techniques for Diagnosing Pancreaticobiliary Malignancy

Overview

Journal F1000Res

Specialties Biomedical Engineering
Science

Date 2017 Sep 26

PMID 28944047

Citations 3

Authors

Margaret G Keane

Amar Shah

Stephen P Pereira

Deepak Joshi

Affiliations

Soon will be listed here.

Abstract

The UK incidence of pancreatic ductal adenocarcinoma is 9 per 100,000 population, and biliary tract cancer occurs at a rate of 1-2 per 100,000. The incidence of both cancers is increasing annually and these tumours continue to be diagnosed late and at an advanced stage, limiting options for curative treatment. Population-based screening programmes do not exist for these cancers, and diagnosis currently is dependent on symptom recognition, but often symptoms are not present until the disease is advanced. Recently, a number of promising blood and urine biomarkers have been described for pancreaticobiliary malignancy and are summarised in this review. Novel endoscopic techniques such as single-operator cholangioscopy and confocal endomicroscopy have been used in some centres to enhance standard endoscopic diagnostic techniques and are also evaluated in this review.

Citing Articles

Biliary Strictures and Cholangiocarcinoma - Untangling a Diagnostic Conundrum.

Ney A, Garcia-Sampedro A, Goodchild G, Acedo P, Fusai G, Pereira S Front Oncol. 2021; 11:699401.

PMID: 34660269 PMC: 8515053. DOI: 10.3389/fonc.2021.699401.

The ambiguous role of microRNA-205 and its clinical potential in pancreatic ductal adenocarcinoma.

Michael Traeger M, Rehkaemper J, Ullerich H, Steinestel K, Wardelmann E, Senninger N J Cancer Res Clin Oncol. 2018; 144(12):2419-2431.

PMID: 30244390 DOI: 10.1007/s00432-018-2755-9.

Differential Roles of Tumor Necrosis Factor Ligand Superfamily Members as Biomarkers in Pancreatic Cancer.

Pombeiro I, Loosen S, Roy S, Schueller F, Niewenhuisen L, Luedde M J Clin Med. 2018; 7(7).

PMID: 30011858 PMC: 6068811. DOI: 10.3390/jcm7070175.

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