Regional Norepinephrine Response to Amphetamine Using Dialysis: Comparison with Caudate Dopamine

Overview

Journal Synapse

Specialty Neurology

Date 1992 Jun 1

PMID 1626314

Citations 13

Authors

R Kuczenski

D S Segal

Affiliations

Soon will be listed here.

Abstract

The response of extracellular norepinephrine to the acute administration of amphetamine was assessed, using dialysis, in prefrontal cortex and hippocampus in awake, behaving rats. Norepinephrine exhibited a pronounced and rapid dose- and time-dependent increase in response to 0.5 and 2.5 mg/kg amphetamine, which corresponded closely to the time course of the behavioral profile. These results are consistent in with a possible role for norepinephrine in the behavioral response to amphetamine.

Citing Articles

Cognition-enhancing and cognition-impairing doses of psychostimulants exert opposing actions on frontostriatal neural coding of delay in working memory.

Spencer R, Martin A, Devilbiss D, Berridge C Neuropsychopharmacology. 2023; 49(5):837-844.

PMID: 37741905 PMC: 10948860. DOI: 10.1038/s41386-023-01738-6.

Critical View on the Usage of Ribavirin in Already Existing Psychostimulant-Use Disorder.

Petkovic B, Kesic S, Pesic V Curr Pharm Des. 2020; 26(4):466-484.

PMID: 31939725 PMC: 8383468. DOI: 10.2174/1381612826666200115094642.

Therapeutic Potential of Selectively Targeting the α-Adrenoceptor in Cognition, Depression, and Schizophrenia-New Developments and Future Perspective.

Uys M, Shahid M, Harvey B Front Psychiatry. 2017; 8:144.

PMID: 28855875 PMC: 5558054. DOI: 10.3389/fpsyt.2017.00144.

Norepinephrine at the nexus of arousal, motivation and relapse.

Espana R, Schmeichel B, Berridge C Brain Res. 2016; 1641(Pt B):207-16.

PMID: 26773688 PMC: 4879075. DOI: 10.1016/j.brainres.2016.01.002.

The cognition-enhancing effects of psychostimulants involve direct action in the prefrontal cortex.

Spencer R, Devilbiss D, Berridge C Biol Psychiatry. 2014; 77(11):940-50.

PMID: 25499957 PMC: 4377121. DOI: 10.1016/j.biopsych.2014.09.013.