Why Drugs Fail--a Study on Side Effects in New Chemical Entities

Overview

Journal Curr Pharm Des

Publisher Bentham Science Publishers

Date 2005 Oct 27

PMID 16248807

Citations 86

Authors

D Schuster

C Laggner

T Langer

Affiliations

Soon will be listed here.

Abstract

Over 90% of the market withdrawals were caused by drug toxicity. Hepatotoxicity and cardiovascular toxicity proved to be the major causes for two out of three market withdrawals in the respective time period. In clinical phases I-III 43% of drug development project terminations were due to insufficient efficacy of the investigated compound. The second important issue, which caused one third of the projects to be closed, was toxicity. ADME parameters and economic and other reasons played a minor role. The results of our study indicate that compared with previous studies on this subject, no major improvements have been achieved in the last decade.

Citing Articles

A Review for Uncovering the "Protein-Nanoparticle Alliance": Implications of the Protein Corona for Biomedical Applications.

Onal Acet B, Gul D, Stauber R, Odabasi M, Acet O Nanomaterials (Basel). 2024; 14(10).

PMID: 38786780 PMC: 11124003. DOI: 10.3390/nano14100823.

Assessment of Quercetin Antiemetic Properties: In Vivo and In Silico Investigations on Receptor Binding Affinity and Synergistic Effects.

Chowdhury R, Bhuia M, Rakib A, Hasan R, Melo Coutinho H, Araujo I Plants (Basel). 2023; 12(24).

PMID: 38140516 PMC: 10747098. DOI: 10.3390/plants12244189.

An overview on the protective effects of ellagic acid against heavy metals, drugs, and chemicals.

Jamshidi Z, Roohbakhsh A, Karimi G Food Sci Nutr. 2023; 11(12):7469-7484.

PMID: 38107104 PMC: 10724599. DOI: 10.1002/fsn3.3704.

Culture methods focusing on bile canalicular formation using primary human hepatocytes in a short time.

Sakai Y, Matsumura M, Iwao T, Matsunaga T In Vitro Cell Dev Biol Anim. 2023; 59(8):606-614.

PMID: 37682508 DOI: 10.1007/s11626-023-00805-y.

MultiGML: Multimodal graph machine learning for prediction of adverse drug events.

Krix S, DeLong L, Madan S, Domingo-Fernandez D, Ahmad A, Gul S Heliyon. 2023; 9(9):e19441.

PMID: 37681175 PMC: 10481305. DOI: 10.1016/j.heliyon.2023.e19441.