Hexylitaconic Acid: a New Inhibitor of P53-HDM2 Interaction Isolated from a Marine-derived Fungus, Arthrinium Sp

Overview

Journal Bioorg Med Chem Lett

Specialty Biochemistry

Date 2005 Oct 26

PMID 16246554

Citations 19

Authors

Sachiko Tsukamoto

Takushi Yoshida

Hidetaka Hosono

Tomihisa Ohta

Hideyoshi Yokosawa

Affiliations

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Abstract

A new inhibitor of p53-HDM2 interaction was isolated from a culture of marine-derived fungus, Arthrinium sp. The structure was identified to be (-)-hexylitaconic acid (1) by spectroscopic analysis. The inhibition of p53-HDM2 binding was tested by the ELISA method, and 1 inhibited the binding with an IC(50) value of 50 microg/mL. Although a number of synthetic inhibitors of p53-HDM2 interaction have been reported so far, 1 is the second inhibitor isolated from natural resources.

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