Identification of the Major Metabolites of Resveratrol in Rat Urine by HPLC-MS/MS

Overview

Journal J Chromatogr B Analyt Technol Biomed Life Sci

Publisher Elsevier

Specialties Biomedical Engineering
Chemistry

Date 2005 Oct 26

PMID 16243591

Citations 24

Authors

Donggeng Wang

Taijun Hang

Chunyong Wu

Wenying Liu

Affiliations

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Abstract

To identify the major metabolites of resveratrol in rat, rat urine samples were pretreated by using solid-phase extraction technique (SPE) with polyamide cartridges. And a LC-MS/MS method with electrospray ionisation (ESI), negative ion mode and collision induced dissociation (CID), was used to elucidate the structures of the major metabolites of resveratrol. According to the results of our experiment, we found that the main metabolites of resveratrol were resveratrol monoglucuronide (M1), dihydroresveratrol monosulfate (M2), resveratrol monosulfate (M3) and dihydroresveratrol (M4).

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