The Plant-Derived Compound Resveratrol in Brain Cancer: A Review

Overview

Journal Biomolecules

Publisher MDPI

Specialties Biochemistry
Molecular Biology

Date 2020 Jan 23

PMID 31963897

Citations 35

Authors

Terezia Kiskova

Peter Kubatka

Dietrich Busselberg

Monika Kassayova

Affiliations

Soon will be listed here.

Abstract

Despite intensive research, malignant brain tumors are among the most difficult to treat due to high resistance to conventional therapeutic approaches. High-grade malignant gliomas, including glioblastoma and anaplastic astrocytoma, are among the most devastating and rapidly growing cancers. Despite the ability of standard treatment agents to achieve therapeutic concentrations in the brain, malignant gliomas are often resistant to alkylating agents. Resveratrol is a plant polyphenol occurring in nuts, berries, grapes, and red wine. Resveratrol crosses the blood‒brain barrier and may influence the central nervous system. Moreover, it influences the enzyme isocitrate dehydrogenase and, more importantly, the resistance to standard treatment via various mechanisms, such as O6-methylguanine methyltransferase. This review summarizes the anticancer effects of resveratrol in various types of brain cancer. Several in vitro and in vivo studies have presented promising results; however, further clinical research is necessary to prove the therapeutic efficacy of resveratrol in brain cancer treatment.

Citing Articles

The Potential Application of Resveratrol and Its Derivatives in Central Nervous System Tumors.

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Nrf2/Keap1/ARE regulation by plant secondary metabolites: a new horizon in brain tumor management.

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Resveratrol Inhibits Nasopharyngeal Carcinoma (NPC) by Targeting the MAPK Signaling Pathway.

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Polyphenols Modulate the miRNAs Expression that Involved in Glioblastoma.

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Comparative Studies of Resveratrol, Oxyresveratrol and Dihydrooxyresveratrol on Doxorubicin-Treated Lung Cancer Cells.

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PMID: 38546076 PMC: 11152376. DOI: 10.31557/APJCP.2024.25.3.939.

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