A Novel One-pot Three-component Reaction: Synthesis of Triheterocyclic 4H-pyrimido[2,1-b]benzazoles Ring Systems

Overview

Journal Bioorg Med Chem Lett

Specialty Biochemistry

Date 2005 Oct 21

PMID 16236502

Citations 5

Authors

Ahmad Shaabani

Abbas Rahmati

Soheila Naderi

Affiliations

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Abstract

A novel one-pot three-component condensation reaction of an aldehyde, beta-ketoester and 2-aminobenzimidazole or 2-aminobenzothiazole in 1,1,3,3-N,N,N',N'-tetramethylguanidinium trifluoroacetate as an ionic liquid is described. During the course of this reaction 4H-pyrimido[2,1-b]benzimidazoles or 4H-pyrimido[2,1-b]benzothiazoles are formed in high yields at 100 degrees C. The ionic liquid can be recovered conveniently and reused efficiently.

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