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Homochiral Growth Through Enantiomeric Cross-inhibition

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Date 2005 Oct 18
PMID 16228640
Citations 6
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Abstract

The stability and conservation properties of a recently proposed polymerization model are studied. The achiral (racemic) solution is linearly unstable once the relevant control parameter (here the fidelity of the catalyst) exceeds a critical value. The growth rate is calculated for different fidelity parameters and cross-inhibition rates. A chirality parameter is defined and shown to be conserved by the nonlinear terms of the model. Finally, a truncated version of the model is used to derive a set of two ordinary differential equations and it is argued that these equations are more realistic than those used in earlier models of that form.

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References
1.
Pooga M, Land T, Bartfai T, Langel U . PNA oligomers as tools for specific modulation of gene expression. Biomol Eng. 2001; 17(6):183-92. DOI: 10.1016/s1389-0344(01)00075-2. View

2.
Nielsen P . Peptide nucleic acid (PNA): a model structure for the primordial genetic material?. Orig Life Evol Biosph. 1993; 23(5-6):323-7. DOI: 10.1007/BF01582083. View

3.
Bonner W . Chirality amplification--the accumulation principle revisited. Orig Life Evol Biosph. 2000; 29(6):615-23. DOI: 10.1023/a:1006646021670. View

4.
Crick F . The origin of the genetic code. J Mol Biol. 1968; 38(3):367-79. DOI: 10.1016/0022-2836(68)90392-6. View

5.
Rasmussen S, Chen L, Nilsson M, Abe S . Bridging nonliving and living matter. Artif Life. 2003; 9(3):269-316. DOI: 10.1162/106454603322392479. View