Homochiral Growth Through Enantiomeric Cross-inhibition
Overview
Molecular Biology
Authors
Affiliations
The stability and conservation properties of a recently proposed polymerization model are studied. The achiral (racemic) solution is linearly unstable once the relevant control parameter (here the fidelity of the catalyst) exceeds a critical value. The growth rate is calculated for different fidelity parameters and cross-inhibition rates. A chirality parameter is defined and shown to be conserved by the nonlinear terms of the model. Finally, a truncated version of the model is used to derive a set of two ordinary differential equations and it is argued that these equations are more realistic than those used in earlier models of that form.
The origin of biological homochirality along with the origin of life.
Chen Y, Ma W PLoS Comput Biol. 2020; 16(1):e1007592.
PMID: 31914131 PMC: 6974302. DOI: 10.1371/journal.pcbi.1007592.
Brandenburg A Orig Life Evol Biosph. 2019; 49(1-2):49-60.
PMID: 31286343 DOI: 10.1007/s11084-019-09579-4.
Deracemization of amino acids by partial sublimation and via homochiral self-organization.
Tarasevych A, Sorochinsky A, Kukhar V, Guillemin J Orig Life Evol Biosph. 2013; 43(2):129-35.
PMID: 23690241 DOI: 10.1007/s11084-013-9333-6.
Mathematical models of the homochiralisation of crystals by grinding.
Wattis J Orig Life Evol Biosph. 2010; 41(2):133-73.
PMID: 20683773 PMC: 3056007. DOI: 10.1007/s11084-010-9221-2.
Gleiser M, Walker S Orig Life Evol Biosph. 2008; 38(4):293-315.
PMID: 18465201 DOI: 10.1007/s11084-008-9134-5.