Drosophila Heartless Acts with Heartbroken/Dof in Muscle Founder Differentiation

Overview

Journal PLoS Biol

Specialty Biology

Date 2005 Oct 7

PMID 16207075

Citations 21

Authors

Devkanya Dutta

Sanjeev Shaw

Tariq Maqbool

Hetal Pandya

K VijayRaghavan

Affiliations

Soon will be listed here.

Abstract

The formation of a multi-nucleate myofibre is directed, in Drosophila, by a founder cell. In the embryo, founders are selected by Notch-mediated lateral inhibition, while during adult myogenesis this mechanism of selection does not appear to operate. We show, in the muscles of the adult abdomen, that the Fibroblast growth factor pathway mediates founder cell choice in a novel manner. We suggest that the developmental patterns of Heartbroken/Dof and Sprouty result in defining the domain and timing of activation of the Fibroblast growth factor receptor Heartless in specific myoblasts, thereby converting them into founder cells. Our results point to a way in which muscle differentiation could be initiated and define a critical developmental function for Heartbroken/Dof in myogenesis.

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