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The Definition of Anemia: What is the Lower Limit of Normal of the Blood Hemoglobin Concentration?

Overview
Journal Blood
Publisher Elsevier
Specialty Hematology
Date 2005 Sep 29
PMID 16189263
Citations 313
Authors
Ernest Beutler
Jill Waalen
Affiliations
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Abstract

The diagnosis of anemia is an important aspect of the practice of hematology. The first step is to decide whether the patient is, in fact, anemic. Unless earlier blood counts are available, and they often are not, the physician must make his or her decision on the basis of the population distribution of hemoglobin values. How likely is it that the patient's hemoglobin value lies below the normal distribution; that is, "the lower limit"?

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References
1.
Cheng C, Chan J, Cembrowski G, van Assendelft O . Complete blood count reference interval diagrams derived from NHANES III: stratification by age, sex, and race. Lab Hematol. 2004; 10(1):42-53. DOI: 10.1532/lh96.04010. View
2.
Perry G, Byers T, Yip R, MARGEN S . Iron nutrition does not account for the hemoglobin differences between blacks and whites. J Nutr. 1992; 122(7):1417-24. DOI: 10.1093/jn/122.7.1417. View
3.
Cook J, Flowers C, Skikne B . The quantitative assessment of body iron. Blood. 2003; 101(9):3359-64. DOI: 10.1182/blood-2002-10-3071. View
4.
JUDY H, Price N . Hemoglobin level and red blood cell count findings in normal women. J Am Med Assoc. 1958; 167(5):563-6. DOI: 10.1001/jama.1958.02990220033010. View
5.
Beutler E, Felitti V, Gelbart T, Waalen J . Haematological effects of the C282Y HFE mutation in homozygous and heterozygous states among subjects of northern and southern European ancestry. Br J Haematol. 2003; 120(5):887-93. DOI: 10.1046/j.1365-2141.2003.04215.x. View