» Articles » PMID: 1617121

Case-control Study of Risk Factors for Cervical Neoplasia in Denmark. II. Role of Sexual Activity, Reproductive Factors, and Venereal Infections

Overview
Specialties Oncology
Public Health
Date 1992 Jul 1
PMID 1617121
Citations 9
Authors
Affiliations
Soon will be listed here.
Abstract

Sexual, reproductive and venereal risk factors for cervical neoplasia were investigated in a population-based case-control study of 586 women with histologically verified, cervical squamous-cell carcinoma in situ, and 59 women with invasive squamous-cell cervical cancer, diagnosed from 1985 to 1986 in Copenhagen. Cases were identified from the computerized Danish Cancer Registry. An age-stratified control group (n = 614) was drawn at random from the female population in the study area by means of the Danish Central Population Register. A structured questionnaire was mailed to cases as well as controls. Increasing number of sexual partners exerted a significant effect on the risk both for carcinoma in situ, and invasive cancer, independently of age at first intercourse and other potential confounders. Conversely, the association with early age at first intercourse became statistically insignificant after allowance for other risk factors, although an increasing risk was still observed with decreasing age at sexual debut. Early age at first episode with genital warts was a significant risk factor for carcinoma in situ, perhaps indicating a possible increased susceptibility of the cervix epithelium during adolescence. A history of genital warts was a good predictor of risk for carcinoma in situ, whereas a history of previous gonorrhea was associated with an increased risk for invasive carcinoma. Women with multiple births had a significantly increased adjusted risk, especially for carcinoma in situ, although some association was also observed with invasive cervical cancer. The study supports the hypothesis of cervical neoplasia being a sexually transmitted disease, and that carcinoma in situ and invasive cervical carcinoma, to a high degree, have similar patterns of risk factors.

Citing Articles

Knowledge about human papillomavirus and prevention of cervical cancer among women of Arkhangelsk, Northwest Russia.

Roik E, Sharashova E, Nieboer E, Kharkova O, Postoev V, Odland J PLoS One. 2017; 12(12):e0189534.

PMID: 29236761 PMC: 5728530. DOI: 10.1371/journal.pone.0189534.


Risk of cancer in patients with genital warts: A nationwide, population-based cohort study in Taiwan.

Cho C, Lo Y, Hung M, Lai C, Chen C, Wu K PLoS One. 2017; 12(8):e0183183.

PMID: 28806741 PMC: 5555692. DOI: 10.1371/journal.pone.0183183.


Restriction endonucleases from invasive Neisseria gonorrhoeae cause double-strand breaks and distort mitosis in epithelial cells during infection.

Weyler L, Engelbrecht M, Mata Forsberg M, Brehwens K, Vare D, Vielfort K PLoS One. 2014; 9(12):e114208.

PMID: 25460012 PMC: 4252111. DOI: 10.1371/journal.pone.0114208.


Human Papillomavirus prevalence and probable first effects of vaccination in 20 to 25 year-old women in Germany: a population-based cross-sectional study via home-based self-sampling.

Delere Y, Remschmidt C, Leuschner J, Schuster M, Fesenfeld M, Schneider A BMC Infect Dis. 2014; 14:87.

PMID: 24552260 PMC: 3933406. DOI: 10.1186/1471-2334-14-87.


Assessing perceived risk and STI prevention behavior: a national population-based study with special reference to HPV.

Leval A, Sundstrom K, Ploner A, Dahlstrom L, Widmark C, Sparen P PLoS One. 2011; 6(6):e20624.

PMID: 21674050 PMC: 3107227. DOI: 10.1371/journal.pone.0020624.


References
1.
Molina R, Thomas D, DABANCENS A, Lopez J, Ray R, Martinez L . Oral contraceptives and cervical carcinoma in situ in Chile. Cancer Res. 1988; 48(4):1011-5. View

2.
Jones C, Brinton L, Hamman R, STOLLEY P, LEHMAN H, Levine R . Risk factors for in situ cervical cancer: results from a case-control study. Cancer Res. 1990; 50(12):3657-62. View

3.
Brock K, Berry G, Brinton L, Kerr C, MACLENNAN R, Mock P . Sexual, reproductive and contraceptive risk factors for carcinoma-in-situ of the uterine cervix in Sydney. Med J Aust. 1989; 150(3):125-30. DOI: 10.5694/j.1326-5377.1989.tb136389.x. View

4.
Kjaer S, POLL P, Jensen H, Engholm G, Haugaard B, Teisen C . Abnormal Papanicolaou smear. A population-based study of risk factors in Greenlandic and Danish women. Acta Obstet Gynecol Scand. 1990; 69(1):79-86. DOI: 10.3109/00016349009021044. View

5.
Fasal E, Simmons M, Kampert J . Factors associated wih high and low risk of cervical neoplasia. J Natl Cancer Inst. 1981; 66(4):631-6. View