N-[(3S)-1-benzylpyrrolidin-3-yl]-(2-thienyl)benzamides: Human Dopamine D4 Ligands with High Affinity for the 5-HT2A Receptor

Overview

Journal Bioorg Med Chem Lett

Specialty Biochemistry

Date 2005 Sep 20

PMID 16168646

Citations 2

Authors

Jalaj Arora

Michel Bordeleau

Laurence Dube

Keith Jarvie

Lucy Mazzocco

Jack Peragine

Ashok Tehim

Ian Egle

Affiliations

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Abstract

A series of N-[(3S)-1-benzylpyrrolidin-3-yl]-(2-thienyl)benzamides 8 has been prepared and found to bind with high affinity to the human D(4) (hD(4)) and 5-HT(2A) receptors. Several compounds displayed selectivity for these receptors versus hD(2) and alpha(1) adrenergic receptors of over 500-fold.

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