An Inception Report on the TOM Complex of the Amoeba Acanthamoeba Castellanii, a Simple Model Protozoan in Mitochondria Studies

Overview

Journal J Bioenerg Biomembr

Publisher Springer

Specialties Biochemistry
Biology
Endocrinology

Date 2005 Sep 17

PMID 16167181

Citations 6

Authors

Malgorzata Wojtkowska

Natalia Szczech

Olgierd Stobienia

Wieslawa Jarmuszkiewicz

Malgorzata Budzinska

Hanna Kmita

Affiliations

Soon will be listed here.

Abstract

It is suggested that in the course of the TOM complex evolution at least two lineages have appeared: the animal-fungal and green plant ones. The latter involves also the TOM complexes of algae and protozoans. The amoeba Acanthamoeba castellanii is a free-living non-photosynthetic soil protozoan, whose mitochondria share many bioenergetic properties with mitochondria of plants, animals and fungi. Here, we report that a protein complex, identified electrophysiologically as the A. castellanii TOM complex, contains a homologue of yeast/animal Tom 70. Further, molecular weight of the complex (about 500 kDa) also points to A. castellanii evolutionary relation with fungi and animal. Thus, the data indicates that the TOM complex of A. castellanii is not a typical example of the protozoan TOM complex.

Citing Articles

The Mitochondrial Outer Membrane Protein Tom70-Mediator in Protein Traffic, Membrane Contact Sites and Innate Immunity.

Kreimendahl S, Rassow J Int J Mol Sci. 2020; 21(19).

PMID: 33019591 PMC: 7583919. DOI: 10.3390/ijms21197262.

Mitochondrial protein import in trypanosomatids: Variations on a theme or fundamentally different?.

Schneider A PLoS Pathog. 2018; 14(11):e1007351.

PMID: 30496284 PMC: 6264148. DOI: 10.1371/journal.ppat.1007351.

The emerging picture of the mitochondrial protein import complexes of Amoebozoa supergroup.

Wojtkowska M, Buczek D, Suzuki Y, Shabardina V, Makalowski W, Kmita H BMC Genomics. 2017; 18(1):997.

PMID: 29284403 PMC: 5747110. DOI: 10.1186/s12864-017-4383-1.

Phylogenetic analysis of mitochondrial outer membrane β-barrel channels.

Wojtkowska M, Jakalski M, Pienkowska J, Stobienia O, Karachitos A, Przytycka T Genome Biol Evol. 2011; 4(2):110-25.

PMID: 22155732 PMC: 3273162. DOI: 10.1093/gbe/evr130.

The TOM complex is involved in the release of superoxide anion from mitochondria.

Budzinska M, Galganska H, Karachitos A, Wojtkowska M, Kmita H J Bioenerg Biomembr. 2009; 41(4):361-7.

PMID: 19690949 DOI: 10.1007/s10863-009-9231-9.

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