Can P503s, P504s and P510s Gene Expression in Peripheral-blood Be Useful As a Marker of Prostatic Cancer?

Overview

Journal BMC Cancer

Publisher Biomed Central

Specialty Oncology

Date 2005 Sep 7

PMID 16143040

Citations 4

Authors

Maria Rosaria Cardillo

Vincenzo Gentile

Antonio Ceccariello

Laura Giacomelli

Stefano Messinetti

Franco Di Silverio

Affiliations

Soon will be listed here.

Abstract

Background: The aim of the study was to investigate whether p503S, p504S and p510S gene expression in peripheral-blood be useful as a diagnostic or prognostic marker of prostatic cancer.

Methods: Circulating cells were identified by reverse transcription-polymerase chain reaction (RT-PCR) to detect p503S, p504S and p510S mRNA in peripheral blood (PB) from 11 patients with treated prostatic carcinoma (CaP), 11 with newly-diagnosed untreated CaP and 20 with benign prostatic hyperplasia (BPH) (controls).

Results: RT-PCR amplified P503S in 7 of 11 untreated and 2 of 11 treated patients with CaP and 5 of 20 with BPH; p504S in 7 of 11 untreated and in 9 of 11 treated patients with CaP and 11 of 20 with BPH; whereas it amplified p510S in all subjects with CaP and in 15 of 20 with BPH.

Conclusion: These findings suggest that the investigated genes are poorly specific and probably of little use as diagnostic or prognostic prostatic markers in peripheral blood for monitoring disease progression and recurrence.

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