OpsX from Haemophilus Influenzae Represents a Novel Type of Heptosyltransferase I in Lipopolysaccharide Biosynthesis

Overview

Journal J Bacteriol

Publisher American Society for Microbiology

Specialty Microbiology

Date 2005 Aug 20

PMID 16109967

Citations 8

Authors

Sabine Gronow

Werner Brabetz

Buko Lindner

Helmut Brade

Affiliations

Soon will be listed here.

Abstract

The inner core region of the lipopolysaccharide (LPS) of Haemophilus influenzae is characterized by the presence of a phosphorylated 3-deoxy-alpha-D-manno-octulosonic acid (Kdo). In this study, we show that the heptosyltransferase I adding the first L-glycero-D-manno-heptose residue to this acceptor is encoded by the gene opsX, which differs in substrate specificity from the other heptosyltransferase I, known as WaaC.

Citing Articles

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Merino S, Knirel Y, Regue M, Tomas J PLoS One. 2013; 8(1):e55546.

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