Tools and Strategies for Physiological Genomics: the Rat Genome Database

Overview

Journal Physiol Genomics

Publisher American Physiological Society

Specialties Genetics
Molecular Biology

Date 2005 Aug 18

PMID 16106031

Citations 6

Authors

Simon N Twigger

Dean Pasko

Jeff Nie

Mary Shimoyama

Susan Bromberg

Dan Campbell

Jiali Chen

Norberto dela Cruz

Chunyu Fan

Cindy Foote

Glenn Harris

Brian Hickmann

Yuan Ji

Weihong Jin

Dawei Li

Jedidiah Mathis

Nataliya Nenasheva

Rajni Nigam

Victoria Petri

Dorothy Reilly

Victor Ruotti

Eric Schauberger

Kathy Seiler

Ronit Slyper

Jennifer Smith

Weiye Wang

Wenhua Wu

Lan Zhao

Angela Zuniga-Meyer

Peter J Tonellato

Anne E Kwitek

Howard J Jacob

Affiliations

Soon will be listed here.

Abstract

The broad goal of physiological genomics research is to link genes to their functions using appropriate experimental and computational techniques. Modern genomics experiments enable the generation of vast quantities of data, and interpretation of this data requires the integration of information derived from many diverse sources. Computational biology and bioinformatics offer the ability to manage and channel this information torrent. The Rat Genome Database (RGD; http://rgd.mcw.edu) has developed computational tools and strategies specifically supporting the goal of linking genes to their functional roles in rat and, using comparative genomics, to human and mouse. We present an overview of the database with a focus on these unique computational tools and describe strategies for the use of these resources in the area of physiological genomics.

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