A Function for the Macrophage F4/80 Molecule in Tolerance Induction

Overview

Journal Trends Immunol

Specialty Allergy & Immunology

Date 2005 Aug 10

PMID 16087400

Citations 41

Authors

Timo K van den Berg

Georg Kraal

Affiliations

Soon will be listed here.

Abstract

The F4/80 monoclonal antibody has been used widely as a marker for mouse macrophages. The antigen (Ag) recognized by the antibody has been characterized as a member of the epidermal growth factor (EGF)-transmembrane 7 (TM7) family, although the function of the molecule has remained elusive. A recent study provides evidence for a role of the F4/80 molecule in the induction of immunological tolerance. This study appears to provide clear evidence for a role of the F4/80 molecule in the immune system, however, what does it really tell us about the activities of the F4/80 molecule?

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