» Articles » PMID: 16084479

The Neurodevelopmental Consequences of Prenatal Alcohol Exposure

Overview
Date 2005 Aug 9
PMID 16084479
Citations 17
Authors
Affiliations
Soon will be listed here.
Abstract

During pregnancy, ingestion of alcohol, a known teratogen, can cause harm to the fetus. Prenatal alcohol exposure is one of the leading causes of birth defects, developmental disorders, and mental retardation in children. The fetal central nervous system is particularly vulnerable to alcohol; this vulnerability contributes to many of the long-term disabilities and disorders seen in individuals with prenatal alcohol exposure. Diagnoses associated with prenatal alcohol exposure include fetal alcohol syndrome (FAS), partial fetal alcohol syndrome, fetal alcohol effects, alcohol-related neurodevelopmental disorder, and alcohol-related birth defects. Once diagnosed, early intervention improves the long-term outcome of affected children. Without documentation of maternal alcohol use, a diagnosis, and consequently treatment, is often difficult to attain. It is imperative that nurses, physicians, and other healthcare providers become comfortable with obtaining a history of, and providing anticipatory guidance and counseling about, alcohol use.

Citing Articles

Ethanol exposure disrupted the formation of radial glial processes and impaired the generation and migration of outer radial glial cells in forebrain organoids derived from human embryonic stem cells.

Lu L, Yuan F, Fan H, Li Y, Liu J, Feng W Exp Neurol. 2023; 362:114325.

PMID: 36669750 PMC: 9992138. DOI: 10.1016/j.expneurol.2023.114325.


Pre-implantation alcohol exposure induces lasting sex-specific DNA methylation programming errors in the developing forebrain.

Legault L, Doiron K, Breton-Larrivee M, Langford-Avelar A, Lemieux A, Caron M Clin Epigenetics. 2021; 13(1):164.

PMID: 34425890 PMC: 8381495. DOI: 10.1186/s13148-021-01151-0.


Lingering Effects of Prenatal Alcohol Exposure on Basal and Ethanol-Evoked Expression of Inflammatory-Related Genes in the CNS of Adolescent and Adult Rats.

Doremus-Fitzwater T, Youngentob S, Youngentob L, Gano A, Vore A, Deak T Front Behav Neurosci. 2020; 14:82.

PMID: 32714160 PMC: 7344178. DOI: 10.3389/fnbeh.2020.00082.


Obstetrician-gynecologists' practices and attitudes on substance use screening during pregnancy.

Ko J, Tong V, Haight S, Terplan M, Stark L, Snead C J Perinatol. 2019; 40(3):422-432.

PMID: 31666646 PMC: 7047638. DOI: 10.1038/s41372-019-0542-3.


Alcohol Use in Pregnancy.

DeJong K, Olyaei A, Lo J Clin Obstet Gynecol. 2018; 62(1):142-155.

PMID: 30575614 PMC: 7061927. DOI: 10.1097/GRF.0000000000000414.