ELL-associated Factors 1 and 2 Are Positive Regulators of RNA Polymerase II Elongation Factor ELL

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2005 Jul 12

PMID 16006523

Citations 57

Authors

Stephanie E Kong

Charles A S Banks

Ali Shilatifard

Joan Weliky Conaway

Ronald C Conaway

Affiliations

Soon will be listed here.

Abstract

In human cells, the ELL family of transcription factors includes at least three members, which are all capable of stimulating the overall rate of elongation by RNA polymerase II by suppressing transient pausing by the enzyme at many sites along DNA. In this report, we identify the ELL-associated factors (EAF)1 and EAF2 as strong positive regulators of ELL elongation activity. Our findings provide insights into the structure and function of ELL family transcription factors, and they bring to light direct roles for the EAF proteins in regulation of RNA polymerase II transcription.

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