Localisation of Intrahepatic Interleukin 6 in Patients with Acute and Chronic Liver Disease

Overview

Journal J Clin Pathol

Specialty Pathology

Date 1992 May 1

PMID 1597519

Citations 7

Authors

S Kakumu

A Fukatsu

T Shinagawa

S Kurokawa

A Kusakabe

Affiliations

Soon will be listed here.

Abstract

Aim: To evaluate the role of local interleukin 6 (IL-6) in the pathogenesis of acute and chronic liver disease.

Methods: The cellular site of IL-6 in cryostat sections of liver from 31 patients with liver disease was examined using indirect immunofluorescence with a monoclonal antibody.

Results: IL-6 staining in sinusoidal endothelial cells was very noticeable and diffusely distributed in the lobules of specimens of acute viral hepatitis. IL-6 expression in endothelial cells, particularly in necrotic areas of hepatocytes, was increased and was accompanied by enhanced expression in Kupffer cells. In contrast, IL-6 staining in infiltrating mononuclear cells was prominent in portal tracts, and the numbers of cytokine positive cells were greater in specimens of chronic active hepatitis compared with chronic persistent hepatitis. In non-specific reactive hepatitis intrahepatic expression of IL-6 was minimal, while in alcoholic liver fibrosis the cytokine distribution in the lobules was similar to that of acute viral hepatitis.

Conclusions: These results indicate that locally produced IL-6 contributes to the inflammatory process and immunological response in acute and chronic liver disease.

Citing Articles

Hepatitis B Virus Middle Protein Enhances IL-6 Production via p38 MAPK/NF-κB Pathways in an ER Stress-Dependent Manner.

Li Y, Ren Y, Fu H, Zou L, Yang Y, Chen Z PLoS One. 2016; 11(7):e0159089.

PMID: 27434097 PMC: 4951109. DOI: 10.1371/journal.pone.0159089.

Treatment with telbivudine positively regulates antiviral immune profiles in Chinese patients with chronic hepatitis B.

Ma L, Cai Y, Yu L, Feng J, Wang J, Li C Antimicrob Agents Chemother. 2013; 57(3):1304-11.

PMID: 23274669 PMC: 3591912. DOI: 10.1128/AAC.02181-12.

HCV+ hepatocytes induce human regulatory CD4+ T cells through the production of TGF-beta.

Hall C, Kassel R, Tacke R, Hahn Y PLoS One. 2010; 5(8):e12154.

PMID: 20730048 PMC: 2921368. DOI: 10.1371/journal.pone.0012154.

HBV replication is significantly reduced by IL-6.

Kuo T, Hu C, Chen Y, Hong M, Jeng K, Liang C J Biomed Sci. 2009; 16:41.

PMID: 19374779 PMC: 2687430. DOI: 10.1186/1423-0127-16-41.

High frequency of autoantibodies in patients with primary sclerosing cholangitis that bind biliary epithelial cells and induce expression of CD44 and production of interleukin 6.

Xu B, Broome U, Ericzon B, Sumitran-Holgersson S Gut. 2002; 51(1):120-7.

PMID: 12077104 PMC: 1773278. DOI: 10.1136/gut.51.1.120.

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