Enteropathogenic Escherichia Coli Type III Effectors EspG and EspG2 Disrupt the Microtubule Network of Intestinal Epithelial Cells

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 2005 Jun 24

PMID 15972534

Citations 35

Authors

Robert K Shaw

Katherine Smollett

Jennifer Cleary

Junkal Garmendia

Ania Straatman-Iwanowska

Gad Frankel

Stuart Knutton

Affiliations

Soon will be listed here.

Abstract

Enteropathogenic Escherichia coli infection of intestinal epithelial cells leads to localized depletion of the microtubule cytoskeleton, an effect that is dependent on delivery of type III translocated effector proteins EspG and Orf3 (designated EspG2) to the site of depletion. Microtubule depletion involved disruption rather than displacement of microtubules.

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