Serial Change of Iodine-123 Metaiodobenzylguanidine (MIBG) Myocardial Concentration in Patients with Dilated Cardiomyopathy

Overview

Journal Eur J Nucl Med

Specialty Nuclear Medicine

Date 1992 Jan 1

PMID 1597243

Citations 12

Authors

K Yamakado

K Takeda

T Kitano

T Nakagawa

Y Futagami

T Konishi

M Hamada

T Nakano

T Ichihara

Affiliations

Soon will be listed here.

Abstract

Serial change of the metaiodobenzylguanidine iodine-123 (123I-MIBG) myocardial concentration was investigated in patients with dilated cardiomyopathy (DCM). Eight DCM patients and 6 control subjects were examined. After the injection of thallium-201 and 123I-MIBG, planar chest images were obtained simultaneously for both tracers in every 30-60 min over 5 h. Serial changes of myocardial uptake ratio (MUR) were compared for both tracers. In DCM, the initial MUR of 123I-MIBG did not differ significantly from that of the controls. The washout of 123I-MIBG from the myocardium, however, was significantly increased in DCM. In particular, the decrease in the early phase (15-45 min) was significantly larger in DCM than in the controls (21.2% +/- 7.5% vs. 5.3% +/- 4.0%, P less than 0.01), showing a significant negative correlation with the left ventricular ejection fraction (r = -0.72 P less than 0.05). For 201Tl, neither the initial MUR nor the washout rate different significantly between the two. Thus, an early rapid decrease of the 123I-MIBG myocardial concentration might characterize DCM and reflect the severity of this disease.

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