Radiolabeled Adrenergi Neuron-blocking Agents: Adrenomedullary Imaging with [131I]iodobenzylguanidine

Overview

Journal J Nucl Med

Specialty Nuclear Medicine

Date 1980 Apr 1

PMID 7381563

Citations 131

Authors

D M Wieland

J Wu

L E Brown

T J Mangner

D P Swanson

W H BEIERWALTES

Affiliations

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Abstract

The tissue distributions of three radioiodinated neuron-blocking agents have been determined in dogs. Iodine-125-labeled meta- and para-iodobenzylguanidines show a striking affinity for, and retention in, the adrenal medulla. Peak concentrations of the two isomers exceed those of previously reported adrenophilic compounds. High myocardial concentrations were also observed at early time intervals. Images of the dog's adrenal medullae have been obtained with para [131I]iodobenzylguanidine.

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