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Dithiolato-bridged Dinuclear Iron-nickel Complexes [Fe(CO)2(CN)2(mu-SCH2CH2CH2S)Ni(S2CNR2)]- Modeling the Active Site of [NiFe] Hydrogenase

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Journal J Am Chem Soc
Specialty Chemistry
Date 2005 Jun 23
PMID 15969562
Citations 19
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Abstract

[NiFe] hydrogenase, the enzyme of which catalyzes the reversible oxidation of molecular hydrogen to protons and electrons, contains a unique heterodinuclear thiolate-bridged Ni-Fe complex in which the iron center is coordinated by CO and CN. We have synthesized dithiolate-bridged Ni-Fe complexes bearing CO and CN ligands to model the active center of [NiFe] hydrogenase. The Ni-Fe complexes containing a [(CN)2(CO)2Fe(mu-S2)NiS2] framework are the closest yet structural models of [NiFe] hydrogenase.

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