Enantioselective Rhodium Enolate Protonations. A New Methodology for the Synthesis of Beta2-amino Acids

Overview

Journal Org Lett

Publisher American Chemical Society

Specialties Biochemistry
Chemistry

Date 2005 Jun 17

PMID 15957893

Citations 11

Authors

Mukund P Sibi

Hiroto Tatamidani

Kalyani Patil

Affiliations

Soon will be listed here.

Abstract

[reaction: see text] Rhodium-catalyzed conjugate addition of an aryl boronic acid to alpha-methylamino acrylates followed by enantioselective protonation of the oxa-pi-allylrhodium intermediate provides access to aryl-substituted beta(2)-amino acids. The impact of the different variables of the reaction on the levels of enantioselectivity has been assessed.

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