BINOL-based Diphosphonites As Ligands in the Asymmetric Rh-catalyzed Conjugate Addition of Arylboronic Acids

Overview

Journal Org Lett

Publisher American Chemical Society

Specialties Biochemistry
Chemistry

Date 2001 Dec 12

PMID 11735590

Citations 8

Authors

M T Reetz

D Moulin

A Gosberg

Affiliations

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Abstract

[reaction: see text] BINOL-based diphosphonites having achiral backbones are useful ligands in the Rh-catalyzed conjugate addition of arylboronic acids to alpha,beta-unsaturated carbonyl compounds. The nature of the achiral backbone determines the direction and degree of enantioselectivity, with er values of up to 99.5:0.5 possible.

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