Synthesis of Isocoumarins Via Pd/C-mediated Reactions of O-iodobenzoic Acid with Terminal Alkynes

Overview

Journal J Org Chem

Publisher American Chemical Society

Specialty Chemistry

Date 2005 Jun 4

PMID 15932318

Citations 10

Authors

Venkataraman Subramanian

Venkateswara Rao Batchu

Deepak Barange

Manojit Pal

Affiliations

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Abstract

The coupling reaction of o-iodobenzoic acid with terminal alkynes by using a catalyst system of 10% Pd/C-Et3N-CuI-PPh3 has been studied in a variety of solvents. 3-Substituted isocoumarins were formed in good yields and with good regioselectivity when the reaction was performed in EtOH.

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