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Learning Spatial Orientation Tasks in the Radial-maze and Structural Variation in the Hippocampus in Inbred Mice

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Publisher Biomed Central
Date 2005 May 27
PMID 15916698
Citations 27
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Abstract

In the present paper we review a series of experiments showing that heritable variations in the size of the hippocampal intra- and infrapyramidal mossy fiber (IIPMF) terminal fields correlate with performance in spatial, but not non-spatial radial-maze tasks. Experimental manipulation of the size of this projection by means of early postnatal hyperthyroidism produces the effects predicted from the correlations obtained with inbred mouse strains. Although the physiological mechanisms behind these correlations are unknown as yet, several lines of evidence indicate that these correlations are causal.

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References
1.
Crusio W, Schwegler H, Lipp H . Radial-maze performance and structural variation of the hippocampus in mice: a correlation with mossy fibre distribution. Brain Res. 1987; 425(1):182-5. DOI: 10.1016/0006-8993(87)90498-7. View

2.
Sluyter F, Marican C, Roubertoux P, Crusio W . Radial maze learning in two inbred mouse strains and their reciprocal congenics for the non-pseudoautosomal region of the Y chromosome. Brain Res. 1999; 835(1):68-73. DOI: 10.1016/s0006-8993(99)01385-2. View

3.
Mineur Y, Sluyter F, de Wit S, Oostra B, Crusio W . Behavioral and neuroanatomical characterization of the Fmr1 knockout mouse. Hippocampus. 2002; 12(1):39-46. DOI: 10.1002/hipo.10005. View

4.
Gerlai R, McNamara A, Williams S, Phillips H . Hippocampal dysfunction and behavioral deficit in the water maze in mice: an unresolved issue?. Brain Res Bull. 2002; 57(1):3-9. DOI: 10.1016/s0361-9230(01)00630-x. View

5.
Staats J . Standardized Nomenclature for Inbred Strains of Mice: eighth listing. Cancer Res. 1985; 45(3):945-77. View