Effect of Inoculum Size on Bacteriolytic Activity of Cefminox and Four Other Beta-lactam Antibiotics Against Escherichia Coli

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 1992 Jan 1

PMID 1590693

Citations 11

Authors

F Soriano

R Edwards

D Greenwood

Affiliations

Soon will be listed here.

Abstract

MICs and turbidimetric experiments revealed a negligible inoculum effect with two Escherichia coli strains exposed to cefminox and cefoxitin, whereas a marked inoculum effect was revealed after exposure to cefotaxime, ceftizoxime, and imipenem. The activities of the cephamycins were associated with spheroplast formation and bacteriolysis at concentrations close to the MIC, whereas the other agents induced the formation of filaments or, in the case of imipenem, rounded cells.

Citing Articles

Purine and pyrimidine synthesis differently affect the strength of the inoculum effect for aminoglycoside and β-lactam antibiotics.

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PMID: 39436125 PMC: 11619438. DOI: 10.1128/spectrum.01895-24.

Purine and pyrimidine synthesis differently affect the strength of the inoculum effect for aminoglycoside and β-lactam antibiotics.

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Growth productivity as a determinant of the inoculum effect for bactericidal antibiotics.

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Inoculum effect of β-lactam antibiotics.

Lenhard J, Bulman Z J Antimicrob Chemother. 2019; 74(10):2825-2843.

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Direct, rapid antimicrobial susceptibility test from positive blood cultures based on microscopic imaging analysis.

Choi J, Jeong H, Lee G, Han S, Han S, Jin B Sci Rep. 2017; 7(1):1148.

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