Aryl-aryl Coupling Via Directed Lithiation and Oxidation
Overview
Affiliations
Aryl lithium reagents formed by directed lithiation reactions undergo transmetallation with copper(I) salts to form organocuprates, which may be efficiently oxidized to yield ortho-substituted biaryls.
Studies on a biomimetic oxidative dimerization approach to the hibarimicins.
Romaine I, Sulikowski G Tetrahedron Lett. 2015; 56(23):3617-3619.
PMID: 26236055 PMC: 4518470. DOI: 10.1016/j.tetlet.2015.01.127.
Assignment and stereocontrol of hibarimicin atropoisomers.
Romaine I, Hempel J, Shanmugam G, Hori H, Igarashi Y, Polavarapu P Org Lett. 2011; 13(17):4538-41.
PMID: 21812391 PMC: 3163008. DOI: 10.1021/ol2017005.